Ribozymes that use redox cofactors *

نویسندگان

  • Shinya Tsukiji
  • Krishna Ramaswamy
  • Hiroaki Suga
چکیده

This review summarizes the history and most recent advances in aptamers and ribozymes that bind and use redox(reduction–oxidation) cofactors. Redox reactions, catalyzed by protein enzymes in an extant world, play a central role in the metabolism of numerous biological molecules in the living organisms. The burden of catalyzing these reactions in a preprotein-based world (i.e., the hypothesized RNA World) could have been borne by RNA molecules. To this end, we raise a fundamental question: can RNA accelerate the redox chemical transformation? We hope that this article will be able to shed light on this intriguing question.

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تاریخ انتشار 2004